Bioelectrical control of positional information in development and regeneration: A review of conceptual and computational advances
…transmembrane potential ()…instructive signals in the spatiotemporal regulation of morphogenesis… extraordinarily strong electric field (∼1.0 × 106 V/m) active over the thin expanse of the plasma membrane, with the capacity to influence a variety of downstream molecular signaling cascades… electrodiffusive transport of charged molecules between cells of the network to generate new positional information patterning possibilities and characteristics… unique properties bioelectricity adds to transport phenomena in gap junction-coupled cell networks to facilitate self-assembly of morphogen gradients and other patterns… essential for a deep understanding of body plan control in development, regeneration and disease.
Alexis Pietak a Michael Levina b
a Allen Discovery Center at Tufts, USA
b Center for Regenerative and Developmental Biology, Tufts University, Medford, MA, USA
Progress in Biophysics and Molecular Biology
Available online 5 April 2018
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