Biomimetic Tooth Repair: Amelogenin-Derived Peptide Enables in Vitro Remineralization of Human Enamel

Abstract

White spot lesions (WSL) and incipient caries on enamel surfaces are the earliest clinical outcomes for demineralization and caries… small peptide domains derived from native protein amelogenin can be utilized to construct a mineral layer on damaged human enamel in vitro… Among the test groups, only the peptide-alone sample resulted in remineralization of fairly thick (10 μm) dense mineralized layer containing HAp mineral, resembling the structure of the healthy enamel. The newly formed mineralized layer exhibited integration with the underlying enamel as evident by cross-sectional imaging…

Authors:
Sami Dogan†, Hanson Fong‡, Deniz T. Yucesoy‡, Timothee Cousin§, Carolyn Gresswell‡, Sefa Dag‡, Greg Huang§, and Mehmet Sarikaya*‡∥⊥
†Department of Restorative Dentistry, ‡GEMSEC, Genetically Engineered Materials Science and Engineering Center and Department of Materials Science and Engineering, §Department of Orthodontics, ∥Deparment of Chemical Engineering, ⊥Department of Oral Health Sciences, University of Washington, Seattle, Washington 98195, United States

ACS Biomaterials Science & Engineering Article ASAP
DOI: 10.1021/acsbiomaterials.7b00959

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Biomimetic Tooth Repair: Amelogenin-Derived Peptide Enables in Vitro Remineralization of Human Enamel

 

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